Enabling this option can make things more realistic but also more difficult in heavy combat. If set to =True, this option allows your squad members to be injured by your fire and vice versa. It is recommended that you instead use the Showhud console command to toggle the HUD on or off at any time - see the Console Commands section. You can still access the main options by pressing ESC, or by pressing the relevant key. If set to =False, this option completely removes the HUD, including all text messages, graphical elements and warnings on the main screen - obviously this can place you at a significant gameplay disadvantage. I only cover what I believe are the most useful of these below: ini file has a wide range of gameplay parameters you can experiment with and alter. Mass Effect Tweak Guide Advanced Tweaking (Pt.3)